How can I fix my computer registry file when my computer is corrupted?

I have a file in the registry called ESQUL. I think it has sys after it. There are five files that constantly come up as corrupt when I scan my computer with SuperAntiSpyware. I delete the files once the scanning is complete, but the file re-appears after re-boot. I have noticed that my computer is running slower. I have tried deleting the file manually, but it doesn't work. It won't allow me to delete the file. I ran different anti-spyware programs, but none of them detect the ESQUL file. I tried running registry cleaners, but I have to pay to delete the findings. I don't know which one is worth it. Can someone pleas help me?